General Clinical Chemistry Analyzers and Accessories
Abcam LY2940680 (Taladegib), 5MG
MW 512.5 Da. Potent Hedgehog signaling pathway inhibitor. Smoothened antagonist. Inhibits growth of cancer cell lines containing a disease-relevant Smoothened gene mutation. Has anti-tumor activity in animal models.
The product is subject to the following: Abcam Restricted Use Statement
GENERAL BIOPHYSICS LLC Argon Gas Analyzer Model A
Thermoconductivity Gas Analyzer for Argon with Onboard PumpApplication: Calibrated for argon gas with onboard pump to take gas samples.Features: Includes data display screen.Accuracy: ±0.9%.
Alkali Scientific Multi Purpose Sample Cups for Clinical Analyzers, 1000/Pk, 3mL (17x38mm)
Polystyrene (PS) Multi Purpose Sample Cups are designed for use with clinical analyzers and automated testing instruments. Manufactured from high clarity polystyrene, these cups provide excellent optical transparency for accurate photometric and chemical analysis. Each cup is precision molded to ensure a secure fit in analyzer sample trays, supporting consistent sample positioning and reliable test results. Compatible with analyzers from Roche Cobas and Elecsys systems, Hitachi, Beckman, and other major platforms, these cups are suitable for handling serum, plasma, urine, calibrators, controls, and reagent samples. The smooth interior surface helps minimize sample retention, improving measurement consistency in clinical, research, and industrial laboratory workflows.
AdipoGen 3-oxo-C14-DL-HSL
Chemical. CAS 503610-29-5. Formula C18H31NO4. MW 325.4. Synthetic. N-3-Oxotetradecanoyl-DL-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. It appears later than shorter acyl chain AHLs in developing biofilms and like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, which in turn inhibits biofilm formation.
Abcam IWP-4, 50MG
MW 496.6 Da, Purity >98%. Potent inhibitor of Wnt pathway regulatory protein porupine (Porcn). Blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways. Blocks palmitylation, and subsquent secretion and activity of Wnt. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AZD1480, 10MG
MW 348.76 Da, Purity >98%. Novel, potent and selective small-molecule JAK2 inhibitor (IC₅₀ < 3 nM). It can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells. Also demonstrates >50-fold selectivity for JAK2 over JAK3.
The product is subject to the following: Abcam Restricted Use Statement
Abcam P 22077, 50MG
MW 315.3 Da, Purity >98%. Selective USP7 (IC₅₀ = 8 μM) inhibitor. Active against closely related USP47. Selective versus SENP2c0re (IC₅₀ >50 μM) and DENI (IC₅₀ >50 μM). Destabilizes Claspin. Inhibits neuroblastoma growth by inducing p53-mediated apoptosis. Inhibits Tip60 deubiquitination.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CHZ868, 5MG
MW 423.4 Da, Purity >=98%. CHZ868 is a potent and selective type II JAK2 inhibitor (IC₅₀ = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist, 50MG
MW 485.5 Da. Potent and selective Smoothened antagonist. Blocks Hedgehog signaling pathway activity (IC₅₀ = 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays. Anti-tumor activity in mouse medulloblastoma allograft model.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen C7-DL-HSL
Chemical. CAS 106983-26-0. Formula C11H19NO3. MW 213.3. Synthetic. N-Heptanoyl-L-homoserine lactone C7-HSL is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence, infection prevention and septicemia in fish.
Abcam SB-525334, TGFBR1 inhibitor., 5MG
MW 343.4 Da, Purity >98%. Cell permeable, potent, selective transforming growth factor beta 1 receptor (ALK5) (IC₅₀ = 14.3 nM) and ALK4 (IC₅₀ = 58.5 nM) inhibitor, with no activity at ALK2, 3 and 6 (IC₅₀ > 10 μM). Blocks fibrosis and renal injury markers in a puromycin-induced nephritis model. Causes significant attenuation in Smad2/3 nuclear translocation and a decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Indo x imod, Indoleamine 2,3-dio x ygenase (IDO) inhibitor, 5G
MW 218.25 Da, Purity >95%. Methylated tryptophan which acts as an Indoleamine 2,3-dioxygenase (IDO) inhibitor. Prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Qstatin, 5MG
MW 293.2 Da, Purity >=98%. A potent, and selective Vibrio QS inhibitor which affects Vibrio harveyi LuxR homologues, the well-conserved master transcriptional regulators for QS in Vibrio species. QStatin binds tightly to a putative ligand-binding pocket in SmcR, the LuxR homologue in V. vulnificus, and changes the flexibility of the protein, thereby altering its transcription regulatory activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Sitravatinib, 25MG
MW 629.7 Da, Purity =98%. Broad spectrum receptor tyrosine kinase inhibitor (e.g. Axl, c-Met, PDGFR, VEGFR, Ephrin receptor family, and FLT3). Better efficacy in mouse models than imatinib and crizotinib.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Methyldymron
Chemical. CAS 42609-73-4. Formula C17H20N2O. MW 268.4. Synthetic. Herbicide. Mode of action is unknow, but most probably by inhibition of plant cell division. Compound can be used as analytical reference material.